Solo wise it's pretty much unplayable imo. Also the skill ceiling on the game is painfully low with CS not being as important as it is in other MOBA games.
I think that is actually one of the things I like more about this game, less emphasis on creeps. I know that is sort of an integral part of MOBAs but I think Smite does a decent job of making up for it in other areas of the game. LoL was a fun game but last I checked it only had 2 or 3 modes to play in. Smite has quite a bit more and that makes it easy to jump into games with at least a semi organized group of players. 1 or 2 friends on = Joust, 2-3 friends on = Domination or Arena, 4 friends = Conquest. Plus there is also a 1v1 Joust mode as well as a daily rotating gimmicky mode (ie Thor only conquest, 100k gold start conquest, etc).
Also, last hitting effectively in Smite will still set you apart from lesser players but it just isn't as significant. Plus in joust clearing one lane of creeps with 3 people is a bit different than someone soloing mid lane in conquest. Joust in general is much more fast paced than conquest.