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More often than I care to admit I'm targeting my partner without realizing it when I'm trying to spam spells on myself. I then find myself mystified by the "insane" amount of damage I'm taking to completely negate not only my heals, but my pain suppression too.
I'm normally made aware of the situation when they start to giggle at me.
I'm only part way through, but it might be helpful to explain the all-too-important blind/vanish-sap/fear combo on your cc target after they've used their trinket earlier on in the game. Often it's possible to down one of your opponents in that time if it's lined up well.
Most notably it's useful in warrior/druid and hunter/druid fights, but can be applied to almost any match up.